Angelini Soñodina Melatonin Tri 1.99 mg, 60 tablets

CONSERVATION AND DACITY

Keep in a cool and dry place.

INGREDIENTS

By tablet:

Stabilizing: microcrystalline cellulose; hydroxypropyleneylcellulose; magnesium stearate; stearic acid; dried extract of Valeriana root officinalis L 100 mg; dry extract of air parts of Passiflora incarnata L. 100 mg; L-triptophane; zinc gluconate; antiaglomerant: silicon dioxide; melatonide

Melatonin 1,99 mg

Passiflora incarnata L.) 100 mg.

Valeriana officinalis L 100 mg.

EMPLEMENTATION MODEL

To help reconcile sleep take 1 tablet a day 1 or 2 hours before bed. It is recommended to always take the tablet at the same time.
To help relieve jet-lag: the first day of travel, take 1 tablet at night, before bed. Repeat the shot for several nights.

OTHER

According to the report of the Scientific Committee of the Spanish Agency for Consumer Affairs, Food Safety and Nutrition (AECOSAN) on conditions of use of certain substances to be used in food supplements: Melatonin

AECOSAN has proposed a maximum daily amount for melatonin of 1 mg. This proposal is based on the authorization of two declarations of healthy properties, in relation to melatonin contributing to

? ease the subjective feeling of time-off (jet lag):

It can only be used with foods that contain a minimum of 0.5 mg of melatonin per quantified portion. For a product to carry this statement, the consumer will be informed that the beneficial effect is obtained with a minimum intake of 0.5 mg that should be taken shortly before bed on the first day of travel and a few days after arrival at the destination (EU, 2012).

? Melatonin helps to reduce the time needed to reconcile sleep

can only be used with foods containing 1 mg melatonin per quantified portion. For a product to carry this statement, the consumer will be informed that the beneficial effect is obtained with a 1 mg intake of melatonin shortly before going to bed (EU, 2012).

Melatonin (N-acetyl-5-metoxytriptamine) is a neurohormone produced by the pineal gland of mammals and other organs, especially the enterochromoformic cells of the gastrointestinal tract and retina (Hardeland et al., 1993) (Huether, 1993), whose main physiological function is the regulation or control of circadian and seasonal rhythms. It was discovered in the 1950s (Lerner et al., 1958, 1959).

In recent years it has been shown that melatonin also has numerous additional functions, is produced and acts in numerous tissues or cells that express melatonin receptors, at much lower levels (Hardeland, 2009). Melatonin receptors MT1 and MT2 (membrane receptors) have been detected in numerous CNS tissues (Central Nervous System), in peripheral organs such as the gastrointestinal tract, liver, lung, skin, adrenal gland, gonadas, male organs, breast tissue, kidney, heart, blood vessels, ephorus, and neutronic tissue. Both receptors involve signaling through AMPc inhibition, protein-kinasa A activity, effects on phospholipase A2 and C, and effects on potassium and calcium channels (Mathes, 2010). A third receptor, MT3, has also been described as an enzyme identified as quinona reductasa 2.

Deficiencies in the production of melatonin or in the expression of receptors or decreases in melatonin levels (such as those that occur with age) result in numerous dysfunctions. In these cases, with insufficient melatonin levels or poor melatoninergic signaling, numerous pathophysiological alterations may occur, reflecting the pleiotropy of the molecule. Thus, for example, a decline in the nocturnal levels of melatonin in patients with neurodegenerative disorders has been observed repeatedly (Uchida et al., 1996).

PRECAUTIONS AND WARNINGS

Food supplements should not be used as substitutes for a balanced diet.
Do not exceed the recommended daily dose.
Keep out of reach of children.

VITAMINS AND MINERALS

By tablet:

Vitamin B6: 1.4 mg.

Zinc: 10 mg.

L-triptophane: 100 mg.